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Similarly, CYP 450 3A4 activity also showed a significant (40%) increase in the GK rat liver and kidney tissues (Figure 3B)

In essence- they cant use or absorb this form of B12it just makes for expensive poo
J Environ Chem Eng 9:106553 Wahab HS, Hussain AA (2016) Photocatalytic oxidation of phenol red onto nanocrystalline TiO2 particles

O'Shea KS & Kaufman MH (1981) Effect of acetaldehyde on the neuroepithelium of early mouser embryos