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7.3 Development of combined intervention strategies The revised section now discusses the potential of combined therapeutic approaches, such as the co-administration of natural bioactive compounds with probiotics or prebiotics, to synergistically regulate gut microbiota composition, restore intestinal barrier integrity, and reduce hepatic oxidative stress and inflammation

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However, long-term mucolytics exposure is associated with inflammation, metabolic syndrome and increased microbial proximity 205

Yang et al., 2011)