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Tramadol abuse, with its risk of physical dependence, opiate use disorder and overdoses, is of concern worldwide and has led to it being a controlled drug in many countries

Fix the cause where possible: diet changes, medication review, or workup for malabsorption

Comment: Several commenters recommended that flat-knit garments have separate codes from circular-knit garments

Clinical observations and research protocols suggest a graduated approach to dosing, beginning with lower doses to assess individual tolerance and response before progressing to higher doses if needed
