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It is a game changer
& Cruz, N
4 Biological role of MTH1 in tumors Tumor cells, characterized by chronic overactivity in mitotic and pro-survival signaling, undergo metabolic changes that generate high levels of oxidants
If immunotherapy aims to establish protective immune memory comparable to that induced by acute infection, then its failure to do socoupled with the insufficient tumor-killing capacity that permits on-treatment progressionreveals fundamental limitations in current strategies and underscores the need for a mechanistic explanation
