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Nearly three decades later, the antigen to which this antibody was directed was identified as the TSH-R (6, 7)

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As we age the cellular NAD + levels decline in part due to the reduced expression of one of the enzymes of NAD + salvage, nicotinamide phosphoribosyl transferase (NAMPT) as well as due to increased NAD + degradation via increased activity of the NAD + and NADP + hydrolyzing enzyme, CD38