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The unique microenvironment of the renal medulla promotes hemoglobin polymerization and subsequent vaso-occlusion, leading to ischemic damage of the renal papillae

Tryptophan supplementation has been shown to reduce stress-related behaviours in fish, such as aggression and hyperactivity, by increasing serotonin levels in the brain [89]

In rare cases in which the catchment area population values were not available, non-weighted means were used in the aggregation

In conclusion, targeting ferroptosis offers a promising new avenue to overcome tumor drug resistance, and through continued mechanistic investigation, technological innovation, and clinical translation, ferroptosis-based therapies are poised to become a central pillar in future cancer treatment paradigms