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The experiment adhered to ARRIVE guidelines and the ethical guidelines of Jilin University and national regulations regarding the welfare of experimental animals, ensuring that the animals had access to water and food

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Dnmt and tet activity assays The Dnmt activity and Tet activity assays were conducted using a Dnmt activity/inhibition assay kit (Epigentek, Farmingdale, NY) and a Tet activity/inhibition direct assay kit (Epigentek, Farmingdale, NY), respectively, following the manufacturers protocols

Other Ingredients: Water, glycerine, natural flavors, phospholipids (from sunflower lecithin), potassium bicarbonate, ethanol, rebaudioside A (from Stevia rebaudiana Leaf), natural citrus and mint oils