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Among the secreted factors, extracellular vesicles (EVs) and mainly exosomes have emerged as novel communication vehicles that have been detected in the TME and are increasingly understood as key players in tumor growth and spread [133,134]
Additional clinical studies are needed to define the optimal oxygenation targets for different disease states
Drug resistance can also depend on cellular autophagic and hypoxic status
Extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them
