glutathione detoxification cancer Intracellular glutathione-depleting polymeric micelles for cisplatin prodrug delivery to overcome cisplatin resistance of cancers Metabolic features of cancer cells

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Some studies indicate that environmental factors, such as nutrition, should additionally be taken into account (Noto et al

Next, the differential abundance analysis was repeated for the entire cohort of PD patients, i.e., comparing 549 patients against 590 controls, using the same statistical approach but including the abundance measurements for the L-DOPA metabolite 3-O-Methyldopa (3-OMD, 3-methoxytyrosine) as an additional covariate to adjust for dopaminergic treatment effects (L-DOPA itself was not covered among the measured metabolites, see section on Study limitations)

Adding back a single amino acid, cysteine or cystine, but no other amino acids, rescued cells from death (Figure 6A, Figure S6A and S6B)