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GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

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To create the ges-1p::cpt-4 , we ligated a 2 kb ges-1 promoter to the coding region of cpt-4 (cloned from N2 genomic DNA) and unc-54 3UTR using Gibson Assembly

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Furthermore, SCFAs might increase anorectic gut hormone secretion, PYY and GLP-1, which may enhance glucose disposal and decrease insulin resistance (61)

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Its worth noting that melanocortin receptors have other roles too theyre involved in pigmentation, appetite, and cardiovascular functions

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