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showed in their genome-wide DNA methylation study of unaffected frontal brain white matter of cALD and AMN patients that oligodendrocyte-differentiation related genes such as MBP, CNP, MOG, and PMP1 were hypermethylated and the genes of immune functions such as IFITM1 and CD59 were hypomethylated [84]

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During fasting, the metabolic shift from glycolysis to fatty acid oxidation reduces mitochondrial ROS generation, thereby improving redox homeostasis [66]