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39 In addition, the reactive aldehydes such as acrolein and 4-hydroxy-2-nonenal (4-HNE) formed from lipid peroxidation cause damage to the epithelial cells, acrolein is unstable and toxic, whereas 4-HNE in high concentrations is capable of inducing caspase (a major promoter of cell apoptosis)
Ghazi-Khansari M, Mojarrab M, Ahmadi F, Hosseinzadeh L
High-dose ascorbic acid may precipitate hemolytic anemia in individuals with G6PD deficiency
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