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We demonstrated that under AILI conditions, PARP1 catalyzed ribosylation of PXR at the residue E194, forming a PARP1PXRCYP3A4 regulatory axis that amplified oxidative stress and NAPQI accumulation through a positive feedback loop

Although studies on mouse models targeted doses of 10/mg/kg/day50 mg/kg/day as harmful without positive effect [100]

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We replaced 250 mg of standard milk thistle extract (80% silymarin) with 160 mg of Siliphos silybin phytosome from Indenathe clinical dosage shown in research to support healthy liver function. Here's why this matters: Standard milk thistle is notoriously poorly absorbed, with only about 2% of the active silybin reaching your bloodstream