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The conjugation reaction was performed by incubating 0.1 mg/mL GSH with 1 M Rhodamine B in PBS for 2 h at room temperature

The subsequent effect on thermal pain sensitivity is opposite for the two compounds, with the diol increasing 622 and the epoxide decreasing pain hypersensitivity

Ageing, smoking, alcohol use and poorly controlled blood sugar add further oxidative load on top
Castro LMR, Gallant M, Niles LP (2005) Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells
