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Availability of data and materials Data described in the manuscript will be available upon request and approval by the UK Biobank ( Declarations Ethics approval and consent to participate This research has been conducted using the UK Biobank Resource under application number 42468 and other large studies and consortia providing publicly available summary statistics

Lactate, as a main product from the glycolytic pathway, is reported to participate in the pro-inflammatory reactions of M1 macrophages (Zhou et al., 2022)
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