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Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71

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While beta-3 receptor density varies between fat depots (higher in visceral, moderate in abdominal subcutaneous, lower in gluteal-femoral), the peptide works systemically

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