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Reduced activity due to an MTHFR mutation can worsen mental health issues
Neuropharmacology 112:399412
Among the SCFAs, butyric acid is the principal energy provider to the colon, intestinal mucosa and intestinal cells, being a primary source of energy for colonocytes, enhancing mitochondrial respiration rate and ATP production [44, 121], serving as a substrate for energy metabolism and being an alternative energy source to prevent the cerebral hypometabolism that causes neuronal dysfunction in AD [44]
