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Pharmacological strategies include medications for T2DM (GLP-1 receptor agonists, SGLT2 inhibitors, biguanides, thiazolidinediones), lipid-lowering drugs (statins, cholesterol absorption inhibitors), antihypertensive drugs, hepatoprotective agents (UDCA, FXR agonists), probiotics/prebiotics/synbiotics targeting the gut microbiota, PPAR agonists, thyroid hormone receptor agonists (THR- agonists), fibroblast growth factor analogs (FGF19/FGF21), and newly developed DNL inhibitors (ACC inhibitors, FAS inhibitors, SCD1 inhibitors, DGAT inhibitors, ketohexokinase inhibitors, MPC inhibitors), miRNAs, and nanoparticles as drug delivery systems

For GSH to reduce a nonnative disulphide bond, it must first glutathionylate one of the cysteine residues

The authors have highlighted the role of newly emerging techniques like gene therapy and CRISPR/Cas9 for the possible treatment of PD