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1170 HK, the enzyme that initiates glycolysis through glucose phosphorylation, is competitively inhibited by 2-deoxyglucose (2-DG), which structurally resembles glucose and binds to HK2, thereby hindering its activity through the accumulation of phosphorylated 2-DG

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Curr Drug Targ 21(13):13851393 Assis VL, Veras AC, Maciel PM, Albuquerque JG, Zancanella C, Ritto JL, Arajo IGA, Veras RC, Medeiros IA (2020) Effects of Funchicrea, a traditional brazilian herbal complex, on intestinal motility in healthy and constipated rodents