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USF1 and USF2, but not c-Myc, can bind to this E-box and overexpression of either one can inhibit the promoter activity (Cheng et al., 2005)

Persistent synovitis can induce VEGF production, promoting neovascularization and increased vascular permeability (143), which may facilitate the influx of iron into the joint cavity and subchondral bone and recruit additional immune cells, thereby intensifying local oxidative stress and inflammatory cascades (144)

Relative risk estimates follow a continuous exposureresponse relationship, derived from meta-analyses of epidemiological studies

Oleanolic acid alleviating ischemia-reperfusion injury in rat severe steatotic liver via KEAP1/NRF2/ARE