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Genistein, a soy isoflavone, is another effector that may control GPx-1 transcription by Nrf1-dependent mechanisms (168, 368)

This gene is part of a family of genes, referred to as the HLA complex, that is strongly associated with common autoimmune diseases including type 1 diabetes, celiac disease, and multiple sclerosis (Kaukinen 2002

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Elis S, et al

Most roseoflavin-resistant strains studied until now carry mutations in the regulatory region upstream of the rib operon (more specifically, in the aptamer of the riboswitch), disrupting the negative feedback mechanism, resulting in significantly higher expression 184,185
