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In general, it is assumed that the two main limiting factors are the levels of cysteine and of the enzyme gamma-glutamyl-cysteine synthetase (also known as glutamate-cysteine ligase)

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Nakazono-Kusaba A, Takahashi-Yanaga F, Morimoto S, Furue M, Sasaguri T

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However, all of the published human studies have used R,S -lipoic acid (racemic mixture)

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There have been hints that some of these behavioral-health-related waivers may be coming to an end

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