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For example, the mono-compartmental models and two compartmental models are models which are commonly divided into 5 compartments (phases), given as follows 1 : Liberation Process of releasing a drug from its pharmaceutical formulation Absorption The process of the substance entering the blood circulation Distribution The dispersion of the substance throughout the fluids and tissue of the body Metabolism The transformation or inactivation of the substance by the organism from parent compounds to daughter metabolites i.e

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