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Kimura, K., Ozeki, M., Juneja, L
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Additionally, preclinical animal studies have indicated that kratom extract mitigates withdrawal symptoms in morphine-dependent rats and produces analgesic effects comparable to conventional opioids, highlighting the role of serotonergic pathways in kratoms mechanism of action [44, 45]

Even beneficial ingredients can trigger a mild inflammatory response as your skin's immune system evaluates the new substance
