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We'll review them to see if they can complement our analysis or if additional specific tests are required
mtDNA is 10 times more vulnerable to mutations and oxidative stress than nDNA due to a lack of histones protection, fewer repair enzymes, and increased susceptibility to supercoiling damage [94]
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Increased iron uptake occurs through upregulation of transferrin receptor 1 and divalent metal transporter 1, coupled with impaired iron export and storage due to reduced expression of ferroportin expression and dysfunction ferritin buffering [205, 206]
