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Research institutions should consider their specific model, measurement endpoints, and practical administration constraints when designing dosing schedules

A recent study also shows that blocking IGF1R-mediated signaling reduces cell proliferation and increases cells sensitivity to the destructive effects of ionizing radiation mediated by down-regulation of BRCA2, a mediator of HR, suggesting that IGF1R is a target for enhancing tumor sensitivity to radiotherapy (Venkatachalam et al., 2017)

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