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1 Introduction Acne vulgaris is a chronic inflammatory disorder of the follicular sebaceous gland unit, with a multifactorial etiology

Being a potential potent inhibitor of LRRK2 kinase activity with low risk for off-target side effects, Vit B12 supplementation in patients with PD (PwPD) seems appealing and encourages future clinical trials to investigate this potent effect as such evidence remains restrained to animal models (Green and Christine 2019) (Fig

doi: 10.1001/jamaophthalmol.2014.5103 120 BartalenaLPiantanidaETandaML

Recently, Akaike and co-workers have shown that Cys-SSH is biosynthesized and attached to tRNA by the cysteinyl tRNA synthetases (CARS), and subsequently is translationally incorporated into proteins