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Additionally, PSA protected against pathogenic infections, intestinal inflammatory diseases and triggered anti-inflammatory signaling pathways by plasmacytoid dendritic cells and the Toll-like receptor-2-mediated CD9 signaling mechanism ( B

Second, aged-rat natural cognitive decline used in McCoy 2013 to test Dihexa in a non-pharmacological cognitive-impairment model

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In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )