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GBD 2019 Dementia Forecasting Collaborators, 2022), there is an urgent need to develop pharmacological therapies to reduce the symptoms of MCI and to delay the possible progression to dementia (Sagaro et al., 2023)

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Digoxigenin-labelled probes were generated by ivt, including DIG-labelled Uracil using pFK i389 Luc NS3-3 JFH1 wt as template, generating 9 or 7 kb DIG-labelled HCV replicon transcripts of complementary polarity for () and (+) HCV RNA probes, respectively