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(PMC) A fourth mechanism is circadian and neuroendocrine regulation, especially through pineal activity and melatonin rhythm normalization

J Nutr Biochem (2014) 25(5):50314.10.1016/j.jnutbio.2013.10.012 68 SokolovAVAgeevaKVPulinaMOZakharovaETVasilyevVB

When applied to the under-eye area, PDGF: Stimulates collagen production to enhance skin firmness and elasticity Improves blood flow to brighten dark circles Strengthens thin, fragile skin to reduce fine lines and crepiness Restores lost volume, creating a smoother, refreshed appearance Instead of masking concerns, PDGF helps your skin naturally repair and renew itself

Briefly, MG detoxification is initiated by the non-enzymatic reaction of this toxic metabolite with a low-molecular-weight thiol such as reduced glutathione (GSH) or bacillithiol, forming a hemithioacetal