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Of note is that although the C/EBP promoter contains no STAT3 DNA binding motif sequences, a novel mechanism indirectly tethering STAT3 to the C/EBP promoter has been described.2426 This result underscores the important role of STAT3 in orchestrating the transforming capacity of NPM-ALK and support studies suggesting STAT3 as a possible therapeutic target.27 C/EBP activity is further regulated through specific phosphorylations that determine its transcriptional activation and DNA binding capacity.24,28,29 The ERK1/2-dependent phosphorylation of human LAP at Thr 235 is a critical priming site required for the transcriptional activation of C/EBP.30 In contrast to a previous study,8 we did not find down-regulation of total C/EBP protein upon pharmacological inhibition of ERK1/2 activation