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Blood-brain barrier transport, plasma pharmacokinetics, and neuropathology following chronic treatment of the rhesus monkey with a brain penetrating humanized monoclonal antibody against the human transferrin receptor

Biol Pharm Bull, 2016;39(3):42834

The prominent feature of OIPN is the presence of sensory peripheral neuropathy, including dysesthesias, numbness, and sensory loss in a distribution resembling a stocking-and-glove pattern, which is possibly concomitant with neuropathic pain and infrequent motor and/or autonomic damage (Argyriou et al., 2007

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation