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It is believed that Se can be non-specifically incorporated into proteins by replacing cysteine or methionine residues ( [Ser]Sec , which also contains some modifications in its anticodon loop, including i6A (N6- isopentenyladenosine) at position 37 and two forms of 5-methoxycarbonylmethyluridine (mcm 5 U and mcm 5 Um) at position 34 (see detailed review by 3.1 Insights into Se application in soils and associated considerations To address Se deficiency in humans, the application of Se-rich fertilizers to soil is recommended

Additional early symptoms include follicular hyperkeratosis, increased susceptibility to infection and cancer and anemia equivalent to iron deficient anemia

doi: 10.1042/BSR20210611

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