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A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibody

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30 The altered NP cell phenotype can maintain the catabolic environment during disc degeneration 31 and has shown to be responsible for the drop in local pH mediated by, among others, acidsensing ion channels (ASICs) 32 that in turn causes IVD cell loss and ECM breakdown