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High-intensity interval training (HIIT) two to three times per week provides metabolic benefits that steady-state cardio cannot match

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One potential strategy involves the fabrication of coreshell particles, where one bioactive agent is loaded into the core structure while another agent is incorporated into the shell phase [262]

Notably, hypothalamic inflammation disrupts POMC neuron functionality through dual mechanisms: cytokine-mediated alteration of neuropeptide secretion profiles, and impaired neuronal plasticity that compromises adaptive energy regulation