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The curcumin and gallic acid -loaded microneedles provide immediate antioxidant and anti-inflammatory effects, alleviating AD symptoms in the short term, while the embedded PLGA needle mediates the sustained release of curcumin for long-term improvement

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Left untreated, a hiatal hernia can cause significant long-term problems, including changes to the esophagus or stomach, and in rare cases, complications like stomach twisting or loss of blood supply. Traditionally, hiatal hernia surgery was invasive, with the introduction of laparoscopic techniques in the 1990s making the procedure less taxing