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Secondly, there are multiple issues in the development of LAM vaccines, including the lack of reliable preclinical evaluation indicators, suitable animal models for vaccine assessment, methods for simulating exposure, unified clinical trial endpoint standards, consistent evaluation environments, and complex immune populations (200)

Additionally, skin irritation tests demonstrated the transdermal films were well-tolerated, showing no signs of erythema or edema even after 72 h of application

Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human -defensins from neutrophils

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