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Disordered -oxidation of long-chain fatty acids in the NSCs of the developing brain caused by L-carnitine deficiency increases the risk of developing ASD in the fetus [8]

Cornelia de Lange syndrome (CdLS) is a rare congenital genetic disorder Cornelia de Lange syndrome (CdLS) Associated symptoms typically include prenatal and postnatal growth delay, a characteristic shape of the craniofacial area, resulting in a distinctive facial appearance, and malformations of the upper limbs

Likewise, metabolites accumulated after long term utilization of pharmacological therapies, such as valproate [79] and the antibiotic cefditoren pivoxil [80], can be conjugated to carnitine and result in carnitine depletion