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Moreover, HDAC inhibition is followed by PPAR upregulation, binding to p-p65 and H3K9Ac modifications on its promoter and eventually suppressing NF-kB-dependent signalling mechanisms (34)

Following oral administration of luteolin to rats, both luteolin and luteolin-7- O -glucoside metabolites are found in plasma samples, while luteolin metabolites such as luteolin-4- O -glucuronide and luteolin-7- O -glucuronide are also detected in the liver, kidneys, and small intestine, which may be associated with the bioactivity in vivo [145]

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