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The activation of PPRE promotes fatty acid oxidation and reduce fatty acid synthesis ( -dependent fatty acid oxidation, leading to lipid accumulation and TGs synthesis, and promote hepatic steatosis ( Figure 4 3.7.3 Others Chronic inflammation is an important pathogenic factor in the liver and accelerates the progression of MASLD and MASH, serum levels of many inflammatory markers and mediators, including C-reactive protein (CRP), tumor necrosis factor (TNF), IL6 and IL8, Interleukin-1 receptor antagonist (IL1RA) and C-X-C motif chemokine ligand 10 (CXCL10), have been examined as diagnostic markers

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