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In this context, NRF2 inhibition leads to the upregulation of miR-181a-2-3p, which directly targets HIF-2, consequently resulting in the attenuation of the HIF-2-mediated CSC phenotype in colorectal cancer cells (Fig

Owing to its exclusive activity towards reduced glutathione, ChaC1 upregulation results in not only glutathione depletion but in alterations in cellular redox ratios (47)

5.1.2.2 Melatonin Melatonin (MLT), or N-acetyl-5-methoxy-tryptamine, is a chemical compound synthesized in the pineal gland and retina from tryptophan and serotonin amino acids

10.1126/science.7732381 39 FingerlinT
