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Blood was collected by submandibular puncture into 1 mL Eppendorf tubes, the plasma was separated and stored in 80 C until used

The sublingual route may offer advantages in terms of absorption and onset of action, but individual patient factors and the specific condition being treated should always be taken into account

Structural Integrity Verification: Confirmation of the 16-amino acid sequence following reconstitution in various laboratory media

Another advantage is that its excretion is handled more by the liver than the kidney, unlike allopurinol, and febuxostat may thus have some advantage in patients with kidney dysfunction