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Vitamin B12 contributes to Energy yielding metabolism Functioning of the nervous system Red blood cell formation Homocysteine metabolism Psychological function Functioning of the immune system Vitamin B12 also plays a role in the process of cell division and the reduction of tiredness and fatigue

The emotional and psychological symptoms of addiction withdrawal are as follows: Anxiety : Withdrawal heightens fear and worry due to dysregulation of neurotransmitters like GABA
Nrf2 can bind to AREs on PINK1 promoter, and then upregulate PINK1 expression and promote mitophagy (Murata et al., 2015
Liu, Gao 2015)