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As a result, L-carnitine with antioxidant and antiapoptotic properties can reduce adverse effects of busulfan on plasma membrane, DNA and mitochondrial integrity through reduction of lipid peroxidation, DNA as well as protein oxidation and decrease busulfan-induced apoptosis

In rare cases, it is also reported that prolong treatment with adefovir even in a low dose of 10 mg can cause adefovir-induced osteomalacia, a metabolic bone disease that leads to softening of the bones

Some studies comment that it helps in the management of pain in 95% of patient's decreases curvature in 30% of patients 14 and decreases the density of the fibrous plaque in approximately 50% of patients 6

10.1016/j.mam.2004.06.004 11 BradyP