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Control experiments with combinations of the constituent amino acids that make up GGC, including L-glutamic acid and L-cysteine, were ineffective
These microenvironmental constraints can limit iron availability, activating adaptive pathways such as HIF-1, which promotes metabolic adaptation and tumor invasiveness ( Due to their rapid growth and proliferation, tumor cells have an increased demand for iron, disrupting iron metabolism
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Hawthorne AB, Daneshmend TK, et al
