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As regards its mechanism of action, in some cell lines Que was able to inhibit the production of TNF in macrophages (Tang et al., 2019), IL-8 in A549 lung cells induced by lipopolysaccharide (LPS) (Geraets et al., 2007), and TNF- and IL-1 mRNA levels in glial cells, causing a decrease in neuronal cell death induced by microglial activation (Li et al., 2016)

Mitochondrial dysfunction, along with the loss of cytochrome c and alterations in cellular redox status, has been shown to affect transforming growth factor beta (TGF-) signaling in fibroblasts, promoting the development of fibrosis (Mohanan et al., 2024)

75 , e13988 (2021)

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