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Medical Conditions, Surgeries, and Medications Lack of intrinsic factor (a protein made in the stomach thats needed for B12 absorption) - this condition is called pernicious anemia Thyroid disease HIV/AIDS (human immunodeficiency virus/acquired immunodeficiency syndrome) Autoimmune diseases like type 1 diabetes, where the immune system in the body attacks its own tissues Gastric bypass surgery (weight loss surgery) Chronic gastritis surgery Certain medications like heartburn drugs (proton pump inhibitors) which reduce stomach acid production Who Is At Risk of Vitamin B12 Deficiency

Eur J Paediatr Neurol 31:3845 Akgun-Unal N, Ozyildirim S, Unal O, Gulbahce-Mutlu E, Mogulkoc R, Baltaci AK (2023) The effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts

Free radical damage to DNA and other cellular structures then accelerates, hastening the senescence of cells