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Gearing and colleagues suppose that A1AT may prevent the release of MMP-12 and TNF-alpha by inhibiting the activity of both thrombin and plasmin ( The clinical-functional impact of A1AT therapy in patients with emphysema associated with A1ATD has been extensively demonstrated through numerous clinical trials

We also demonstrated that there are regions in which this synergetic behavior plays a dominant role

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2002;282:E1139E1146