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Evidence on the mode of action of metformin shows that it improves insulin sensitivity by increasing insulin receptor tyrosine kinase activity and enhancing glycogen synthesis in hepatocytes, and by increasing recruitment and transport of GLUT4 transporters to the plasma membrane in adipose tissue

Through intricate crosstalk with these diverse signaling cascades, HIF-1 modulates the secretion of inflammatory factors and participates in the regulation of various cellular processes, including survival, proliferation, metabolism, angiogenesis, and inflammatory responses

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