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Furthermore, pilot studies or studies in highly specialized populations (such as elite athletes) often have smaller sample sizes due to the difficulty of recruiting participants who meet the strict inclusion criteria

Trimethylamine oxide: A potential target for heart failure therapy

Likewise, in the VADT study including 1,791 military veterans (mean age, 60.4 years) who had a suboptimal response to therapy for type 2 diabetes, after a median follow-up of 5.6 years no differences between the two groups on intensive or standard glucose control were observed for DSPN or microvascular complications 117

These agents can also be administered in conjunction with KRT but will be dialysed along with other small molecules